| Item Type | Name |
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Academic Article
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Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation.
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Academic Article
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Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.
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Academic Article
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Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
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Academic Article
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Mitochondria: a therapeutic target in neurodegeneration.
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Academic Article
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Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.
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Academic Article
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Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons.
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Academic Article
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NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide.
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Academic Article
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Novel therapeutics for Alzheimer's disease: an update.
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Academic Article
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Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.
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Academic Article
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Mitochondria: the missing link between preconditioning and neuroprotection.
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Academic Article
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Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.
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Academic Article
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Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease.
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Academic Article
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DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease.
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Academic Article
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The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
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Academic Article
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The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.
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Academic Article
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Signaling effect of amyloid-beta(42) on the processing of AbetaPP.
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Academic Article
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Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
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Academic Article
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Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers.
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Academic Article
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Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.
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Academic Article
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Widespread distribution of reticulon-3 in various neurodegenerative diseases.
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Academic Article
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Biomarkers in Alzheimer's disease: past, present and future.
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Academic Article
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Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis.
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Academic Article
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AGEs/RAGE complex upregulates BACE1 via NF-?B pathway activation.
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Academic Article
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Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.
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Academic Article
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Cellular prion protein is essential for oligomeric amyloid-?-induced neuronal cell death.
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Academic Article
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Amyloid-? peptide structure in aqueous solution varies with fragment size.
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Academic Article
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Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
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Academic Article
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Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest.
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Academic Article
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The structures of the E22? mutant-type amyloid-? alloforms and the impact of E22? mutation on the structures of the wild-type amyloid-? alloforms.
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Academic Article
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A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
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Academic Article
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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
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Academic Article
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Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy.
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Academic Article
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Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
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Academic Article
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Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress.
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Academic Article
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Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
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Academic Article
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Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease.
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Academic Article
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Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease.
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Academic Article
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Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease.
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Academic Article
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Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.
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Academic Article
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A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes.
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Academic Article
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Chronic effects of mild neurotrauma: putting the cart before the horse?
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Academic Article
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Tau, Amyloid Beta and Deep Brain Stimulation: Aiming to Restore Cognitive Deficit in Alzheimer's Disease.
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Academic Article
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Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
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Academic Article
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Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.
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Academic Article
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Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease.
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Academic Article
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Elongation affinity, activation barrier, and stability of A?42 oligomers/fibrils in physiological saline.
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Academic Article
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1,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins.
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Academic Article
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Estrogen receptor-a is localized to neurofibrillary tangles in Alzheimer's disease.
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Academic Article
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Fibrillar Amyloid-? Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3?Tg-AD Transgenic Mouse.
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Academic Article
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Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
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Academic Article
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Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to ? sheet in tau protein linked to Alzheimer's disease.
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Academic Article
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Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model.
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Academic Article
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Affinity and path of binding xylopyranose unto E.?coli xylose permease.
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Academic Article
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Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens.
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Academic Article
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Precision pharmacology for Alzheimer's disease.
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Academic Article
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Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies.
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Academic Article
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Analysis of post-translational modifications in Alzheimer's disease by mass spectrometry.
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Academic Article
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The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease.
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Academic Article
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Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges.
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Academic Article
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TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease.
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Academic Article
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Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders.
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Academic Article
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Incubation with Cu(II) and Zn(II) salts enhances MALDI-TOF mass spectra of amyloid-beta and a-synuclein toward in vivo analysis.
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Academic Article
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Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer's Diseased Brains by MALDI-TOF MS with MS/MS.
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Academic Article
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Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
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Academic Article
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Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model.
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Academic Article
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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles.
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Academic Article
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No Evidence of Increased Chronic Traumatic Encephalopathy Pathology or Neurodegenerative Proteinopathy in Former Military Service Members: A Preliminary Study.
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Academic Article
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Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.
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Academic Article
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Differences in structure and function between human and murine tau.
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Academic Article
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TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration.
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Academic Article
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TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
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Academic Article
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Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances.
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Academic Article
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Decreased salivary lactoferrin levels are specific to Alzheimer's disease.
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Academic Article
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High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
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Academic Article
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Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
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Academic Article
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Predicting the failure of amyloid-beta vaccine.
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Academic Article
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The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
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Academic Article
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Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.
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Academic Article
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The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
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Academic Article
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Amyloid-beta: a (life) preserver for the brain.
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Academic Article
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Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
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Academic Article
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Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
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Academic Article
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Academic Article
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4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis.
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Academic Article
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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
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Academic Article
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Distribution, levels, and activation of MEK1 in Alzheimer's disease.
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Academic Article
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Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply.
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Academic Article
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Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
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Academic Article
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Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
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Academic Article
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Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.
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Academic Article
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Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
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Academic Article
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Alzheimer's disease: the two-hit hypothesis.
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Academic Article
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Heme catabolism and heme oxygenase in neurodegenerative disease.
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Academic Article
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Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
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Academic Article
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Oxidative stress increases expression and activity of BACE in NT2 neurons.
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Academic Article
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The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.
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Academic Article
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Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain.
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Academic Article
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Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells.
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Academic Article
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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.
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Academic Article
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JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.
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Academic Article
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Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
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Academic Article
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Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
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Academic Article
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Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
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Academic Article
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Increased p27, an essential component of cell cycle control, in Alzheimer's disease.
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Academic Article
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Hydroxynonenal, toxic carbonyls, and Alzheimer disease.
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Academic Article
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Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway.
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Academic Article
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Oxidative damage in the olfactory system in Alzheimer's disease.
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Academic Article
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Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
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Academic Article
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Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
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Academic Article
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Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.
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Academic Article
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Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.
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Academic Article
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Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
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Academic Article
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Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.
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Academic Article
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Perspectives on the amyloid-beta cascade hypothesis.
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Academic Article
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Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.
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Academic Article
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Neuroprotective properties of Bcl-w in Alzheimer disease.
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Academic Article
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Tau phosphorylation and assembly.
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Academic Article
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Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells.
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Academic Article
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Concealment of epitope by reduction and alkylation in prion protein.
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Academic Article
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Tau modifiers as therapeutic targets for Alzheimer's disease.
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Academic Article
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Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
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Academic Article
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Therapeutic potential of oxidant mechanisms in Alzheimer's disease.
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Academic Article
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MAPKs are differentially modulated in arctic ground squirrels during hibernation.
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Academic Article
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The cell cycle in Alzheimer disease: a unique target for neuropharmacology.
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Academic Article
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Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers.
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Academic Article
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A second look into the oxidant mechanisms in Alzheimer's disease.
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Academic Article
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P38 activation mediates amyloid-beta cytotoxicity.
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Academic Article
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Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
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Academic Article
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Neuropathology of Alzheimer disease: pathognomonic but not pathogenic.
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Academic Article
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Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
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Academic Article
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Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
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Academic Article
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Alzheimer disease, the two-hit hypothesis: an update.
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Academic Article
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c-Jun phosphorylation in Alzheimer disease.
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Academic Article
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Treating the lesions, not the disease.
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Academic Article
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Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.
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Academic Article
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Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
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Academic Article
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Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease.
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Academic Article
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Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
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Academic Article
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Tau phosphorylation in Alzheimer's disease: pathogen or protector?
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Academic Article
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Assembly in vitro of tau protein and its implications in Alzheimer's disease.
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Academic Article
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Alzheimer's disease: an intracellular movement disorder?
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Academic Article
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4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
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Academic Article
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Metal ions and oxidative protein modification in neurological disease.
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Academic Article
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Chitin-like polysaccharides in Alzheimer's disease brains.
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Academic Article
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Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
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Academic Article
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Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.
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Academic Article
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Compensatory responses induced by oxidative stress in Alzheimer disease.
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Academic Article
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Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.
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Academic Article
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Therapeutic options in Alzheimer's disease.
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Academic Article
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Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
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Academic Article
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LRRK2 protein is a component of Lewy bodies.
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Academic Article
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Increased expression of p130 in Alzheimer disease.
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Academic Article
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Apoptosis in Alzheimer disease: a mathematical improbability.
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Academic Article
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Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.
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Academic Article
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Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
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Academic Article
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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
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Academic Article
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Physiological regulation of tau phosphorylation during hibernation.
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Academic Article
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Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
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Academic Article
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Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease.
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Academic Article
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Alzheimer disease pathology as a host response.
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Academic Article
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Phosphorylated tau: toxic, protective, or none of the above.
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Academic Article
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Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
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Academic Article
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Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.
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Academic Article
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Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
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Academic Article
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The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells.
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Academic Article
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The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.
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Academic Article
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Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches.
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Academic Article
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Tau--an inhibitor of deacetylase HDAC6 function.
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Academic Article
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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
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Academic Article
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Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease.
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Academic Article
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BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
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Academic Article
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Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage.
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Academic Article
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
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Academic Article
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Stem cell niches as clinical targets: the future of anti-ischemic therapy?
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Academic Article
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The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
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Academic Article
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Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress.
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Academic Article
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Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.
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Academic Article
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From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).
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Concept
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Acute-Phase Proteins
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Concept
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Serum Amyloid A Protein
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Concept
|
Anion Exchange Protein 1, Erythrocyte
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Concept
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Blood Proteins
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Concept
|
Calcium-Binding Proteins
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Concept
|
Calmodulin-Binding Proteins
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Concept
|
Carrier Proteins
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Concept
|
Complement System Proteins
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Concept
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Cytoskeletal Proteins
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Concept
|
DNA-Binding Proteins
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Concept
|
Glial Fibrillary Acidic Protein
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Concept
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Heat-Shock Proteins
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|
Concept
|
Intermediate Filament Proteins
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|
Concept
|
Iron-Sulfur Proteins
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|
Concept
|
Luminescent Proteins
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Concept
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Membrane Proteins
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Concept
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Microfilament Proteins
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Concept
|
Microtubule Proteins
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Concept
|
Microtubule-Associated Proteins
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|
Concept
|
Monosaccharide Transport Proteins
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|
Concept
|
Muscle Proteins
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|
Concept
|
S100 Proteins
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|
Concept
|
Nerve Tissue Proteins
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|
Concept
|
Nuclear Proteins
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Protein Denaturation
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Concept
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Protein Kinases
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Concept
|
Protein Precursors
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Concept
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Protein Processing, Post-Translational
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|
Concept
|
Protein-Tyrosine Kinases
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|
Concept
|
Proteins
|
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Concept
|
Proto-Oncogene Proteins
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|
Concept
|
Recombinant Fusion Proteins
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|
Concept
|
Recombinant Proteins
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Concept
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Repressor Proteins
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Concept
|
Protein Biosynthesis
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Concept
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Protozoan Proteins
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Concept
|
Tumor Suppressor Protein p53
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Concept
|
Retinoblastoma Protein
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Concept
|
Amyloid beta-Protein Precursor
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|
Concept
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RNA-Binding Proteins
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|
Concept
|
Proto-Oncogene Proteins c-jun
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Concept
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tau Proteins
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Concept
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Neurofilament Proteins
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Concept
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Protein Structure, Secondary
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Concept
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Protein Structure, Tertiary
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Concept
|
Protein Folding
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Concept
|
MyoD Protein
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Concept
|
Cyclic AMP-Dependent Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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PrPSc Proteins
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Concept
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PrPC Proteins
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Concept
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Cell Cycle Proteins
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Concept
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HSP70 Heat-Shock Proteins
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Concept
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HSP90 Heat-Shock Proteins
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Concept
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Proto-Oncogene Proteins c-bcl-2
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Concept
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BRCA1 Protein
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Concept
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Protein Disulfide-Isomerases
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Concept
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Mitogen-Activated Protein Kinase 1
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Concept
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Protein Isoforms
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Concept
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I-kappa B Proteins
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Concept
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rab GTP-Binding Proteins
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Mitogen-Activated Protein Kinase Kinases
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Mitochondrial Proteins
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Concept
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HMGB1 Protein
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Concept
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BRCA2 Protein
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Concept
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Tumor Suppressor Proteins
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Concept
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Membrane Transport Proteins
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Concept
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Anion Transport Proteins
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Concept
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Cation Transport Proteins
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Concept
|
Saccharomyces cerevisiae Proteins
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Concept
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Drosophila Proteins
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Concept
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Escherichia coli Proteins
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Concept
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Mitochondrial Membrane Transport Proteins
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Concept
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Iron-Regulatory Proteins
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Concept
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Iron Regulatory Protein 1
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Concept
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Iron Regulatory Protein 2
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Concept
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Ribosomal Protein S6
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Concept
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Ribosomal Protein S6 Kinases, 90-kDa
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Concept
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Receptors, G-Protein-Coupled
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Electron Transport Chain Complex Proteins
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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JNK Mitogen-Activated Protein Kinases
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Concept
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p38 Mitogen-Activated Protein Kinases
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Concept
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Mitogen-Activated Protein Kinase 3
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Concept
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Mitogen-Activated Protein Kinase 8
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Concept
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Mitogen-Activated Protein Kinase 9
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Concept
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Mitogen-Activated Protein Kinase 10
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Concept
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Adaptor Proteins, Signal Transducing
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Concept
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Green Fluorescent Proteins
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Concept
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Mutant Proteins
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Concept
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Retinoblastoma-Like Protein p130
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Concept
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CREB-Binding Protein
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Concept
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bcl-2 Homologous Antagonist-Killer Protein
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Concept
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Apoptosis Regulatory Proteins
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Concept
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bcl-X Protein
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Concept
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bcl-Associated Death Protein
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Concept
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bcl-2-Associated X Protein
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Concept
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Proto-Oncogene Proteins c-akt
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Concept
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Glucose Transport Proteins, Facilitative
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Concept
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Wiskott-Aldrich Syndrome Protein Family
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Concept
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Wiskott-Aldrich Syndrome Protein, Neuronal
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Concept
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Xeroderma Pigmentosum Group A Protein
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Concept
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Sterol Regulatory Element Binding Protein 2
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Concept
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Smad Proteins
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Concept
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Smad2 Protein
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Concept
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Amyloid Precursor Protein Secretases
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Concept
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Protein Phosphatase 2
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Concept
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Concept
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G-Protein-Coupled Receptor Kinase 2
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Concept
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Protein Multimerization
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Academic Article
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Mechanisms by which metals promote events connected to neurodegenerative diseases.
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Academic Article
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What is aging? What is its role in Alzheimer's disease? What can we do about it?
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Academic Article
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?-amyloid 1-42 induces physiological transcriptional regulation of BACE1.
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Academic Article
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Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links.
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Academic Article
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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
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Academic Article
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Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?
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Academic Article
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Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease.
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Academic Article
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An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1.
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Academic Article
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Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.
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Academic Article
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Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease.
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Academic Article
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National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in M?xico.
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Academic Article
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Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults.
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Academic Article
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Lester (Skip) Binder (1949-2013): in the beginning was tau.
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Academic Article
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Status and future directions of clinical trials in Alzheimer's disease.
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Academic Article
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Serial reconstruction of beta-protein amyloid plaques: relationship to microvessels and size distribution.
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Academic Article
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Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities.
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Academic Article
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Filaments of Lewy bodies contain insoluble cytoskeletal elements.
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Academic Article
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Derivation and characterization of glycoinositol-phospholipid anchor-defective human K562 cell clones.
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Academic Article
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Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.
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Academic Article
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Immunohistochemical recognition of ethylnitrosourea induced rat brain microtumors by anti-Leu 7 monoclonal antibody.
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Academic Article
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Age-dependent pattern of intermediate filament protein expression in the human pineal gland.
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Academic Article
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Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.
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Academic Article
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Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.
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Academic Article
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Coexistence of cytokeratin, vimentin and neurofilament protein in human choroid plexus. An immunohistochemical study of intermediate filaments in neuroepithelial tissues.
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Academic Article
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Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles.
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Academic Article
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Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease.
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Academic Article
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Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau.
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Academic Article
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Tau-reactive neurofibrillary tangles in cerebellar cortex from patients with Alzheimer's disease.
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Academic Article
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Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
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Academic Article
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Immunolocalization of the amyloid precursor protein within the senile plaque.
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Academic Article
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Amyloid precursor protein in senile plaques of Alzheimer disease.
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Academic Article
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The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types.
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Academic Article
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The glucose transporter of the human brain and blood-brain barrier.
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Academic Article
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Filaments of Pick's bodies contain altered cytoskeletal elements.
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Academic Article
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Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
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Academic Article
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Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.
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Academic Article
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Cytokeratin expression in human spinal meninges and ependymal cells.
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Academic Article
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Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.
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Academic Article
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Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease.
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Academic Article
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Abnormal tau-reactive filaments in olfactory mucosa in biopsy specimens of patients with probable Alzheimer's disease.
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Academic Article
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Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton.
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Academic Article
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Glucose transporters are abundant in cells with "occluding" junctions at the blood-eye barriers.
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Academic Article
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The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease.
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Academic Article
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Immunocytochemical localization of the erythroid glucose transporter: abundance in tissues with barrier functions.
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Academic Article
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The presence of tau distinguishes Lewy bodies of diffuse Lewy body disease from those of idiopathic Parkinson disease.
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Academic Article
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The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition.
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Academic Article
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Amyloid precursor protein in cell cultures: a 130 kDa polypeptide.
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Academic Article
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Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes.
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Academic Article
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Hirano body filaments contain actin and actin-associated proteins.
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Academic Article
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Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy.
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Academic Article
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Hirano bodies contain tau protein.
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Academic Article
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Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.
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Academic Article
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Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease.
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Academic Article
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Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains.
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Academic Article
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Early AGEing and Alzheimer's.
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Academic Article
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Barrier properties of testis microvessels.
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Academic Article
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Alzheimer's disease and prion proteins: a meeting made in muscle.
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Academic Article
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Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease.
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Academic Article
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The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion.
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Academic Article
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beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
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Academic Article
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Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
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Academic Article
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APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology.
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Academic Article
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Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice.
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Academic Article
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alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease.
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Academic Article
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Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease.
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Academic Article
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Trypsin interaction with the senile plaques of Alzheimer disease is mediated by beta-protein precursor.
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Academic Article
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Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions.
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Academic Article
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Production of monoclonal antibodies against calmodulin by in vitro immunization of spleen cells.
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Academic Article
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Association of apolipoprotein E with murine amyloid A protein amyloid.
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Academic Article
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Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.
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Academic Article
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T-cell reconstitution by molecular, phenotypic, and functional analysis in the thymus, bone marrow, spleen, and blood following split-dose polychemotherapy and therapeutic activity for metastatic breast cancer in mice.
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Academic Article
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Amyloid P component and other acute-phase proteins associated with cerebellar A beta-deposits in Alzheimer's disease.
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Academic Article
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Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.
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Academic Article
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Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.
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Academic Article
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Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.
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Academic Article
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Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles.
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Academic Article
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Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
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Academic Article
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Radical AGEing in Alzheimer's disease.
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Academic Article
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Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease.
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Academic Article
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beta-Amyloid of Alzheimer's disease induces reactive gliosis that inhibits axonal outgrowth.
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Academic Article
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Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.
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Academic Article
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Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.
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Academic Article
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Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system.
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Academic Article
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Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers.
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Academic Article
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Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
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Academic Article
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Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
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Academic Article
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Is amyloid beta-protein glycated in Alzheimer's disease?
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Academic Article
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Levuglandin E2-protein adducts in human plasma and vasculature.
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Academic Article
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Alzheimer disease: protein-protein interaction and oxidative stress.
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Academic Article
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Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
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Academic Article
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Abnormal localization of iron regulatory protein in Alzheimer's disease.
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Academic Article
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Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
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Academic Article
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Altered glycosylation pattern of proteins in Alzheimer disease.
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Academic Article
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Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease.
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Academic Article
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The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction.
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Academic Article
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CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.
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Academic Article
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In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
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Academic Article
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Prion protein glycosylation is sensitive to redox change.
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Academic Article
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How important is oxidative damage? Lessons from Alzheimer's disease.
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Academic Article
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In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
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Academic Article
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Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.
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Academic Article
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Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.
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Academic Article
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Protein disulfide isomerase in Alzheimer disease.
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Academic Article
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Biochemistry of neurodegeneration.
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Academic Article
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Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease.
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Academic Article
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Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
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Academic Article
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Early glycoxidation damage in brains from Down's syndrome.
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Academic Article
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Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
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Academic Article
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Is oxidative damage central to the pathogenesis of Alzheimer disease?
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Academic Article
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A suicide note from Alzheimer disease neurons?
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Academic Article
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Universal isolation of cross-linked peptides: application to neurofibrillary tangles.
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Academic Article
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Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
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Academic Article
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Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
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Academic Article
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In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.
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Academic Article
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Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau.
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Academic Article
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Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease.
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Academic Article
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Lipoperoxidation is selectively involved in progressive supranuclear palsy.
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Academic Article
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Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.
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Academic Article
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Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
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Academic Article
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Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal.
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Academic Article
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Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.
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Academic Article
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Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease.
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Academic Article
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Abortive apoptosis in Alzheimer's disease.
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Academic Article
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Chemistry and biochemistry of oxidative stress in neurodegenerative disease.
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Academic Article
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Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
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Academic Article
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Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
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Academic Article
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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
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Academic Article
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Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy.
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Academic Article
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Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits.
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Academic Article
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Possible protective mechanisms of heme oxygenase-1 in the brain.
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Academic Article
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Neurofilament proteins in neurodegenerative diseases.
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Academic Article
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Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.
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Academic Article
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Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
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Academic Article
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Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms.
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Academic Article
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Brain and brawn: parallels in oxidative strength.
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Academic Article
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Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology.
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Academic Article
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Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
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Academic Article
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Prospects on the origin of Alzheimer's disease.
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Academic Article
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A novel perspective on tau in Alzheimer's disease.
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Academic Article
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Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome.
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Academic Article
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Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
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Academic Article
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Inhibition of Calpain Protects Against Tauopathy in Transgenic P301S Tau Mice.
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Academic Article
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Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest.
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Academic Article
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Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study.
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Academic Article
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Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.
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Grant
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RCMI Center for Interdiscplinary Health Research CIHR
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Grant
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RCMI Center for Interdiscplinary Health Research CIHR
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Grant
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AMYLOID PRECURSOR IN ALZHEIMER DISEASE
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Grant
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NEUROFIBRILLARY PATHOLOGY IN ALZHEIMER DISEASE
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Academic Article
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Ethanol-Fixed, Paraffin-Embedded Tissue Imaging: Implications for Alzheimer's Disease Research.
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Academic Article
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Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration.
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Academic Article
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A Multilevel View of the Development of Alzheimer's Disease.
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Academic Article
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Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review.
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Academic Article
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Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy.
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Academic Article
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Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria.
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Academic Article
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The Amyloid-? Pathway in Alzheimer's Disease.
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Academic Article
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The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes.
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Academic Article
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Memory, Sleep, and Tau Function.
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Academic Article
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MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.
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Academic Article
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Passive Alzheimer's immunotherapy: A promising or uncertain option?
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Academic Article
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Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village.
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Academic Article
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Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on a-Synuclein and Tau Aggregation.
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Academic Article
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Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice.
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